Poor Prognosis and High Recurrence in NTRK3 Fusion Cervical Sarcoma: A Series of 3 Cases and Literature…

StudyInternational journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists· Sep 2026

Poor Prognosis and High Recurrence in NTRK3 Fusion Cervical Sarcoma: A Series of 3 Cases and Literature Review.

Wan Xiong, Junbo Hu, Zhigan Wang … Qiongrong Chen

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Breast & Gynecologic PathologyStudyQ1IF 2.1

All three patients with NTRK3-fusion cervical sarcoma in this case series experienced recurrence.

Poor Prognosis and High Recurrence in NTRK3 Fusion Cervical Sarcoma: A Series of 3 Cases and Literature Review.

Wan Xiong … Qiongrong Chen

International journal of gynecological pathology · Sep 2026 · Q1 in Pathology

Purpose

This study aimed to expand the morphologic and molecular spectrum of NTRK-rearranged uterine tumors by reporting 3 cases of NTRK3-fusion cervical sarcoma and conducting a literature review, thereby strengthening the understanding of their clinicopathologic features, differential diagnosis and treatments.

Methods

We collected 3 cases of NTRK3-fusion cervical sarcoma and reviewed their clinical presentation, histomorphology, immunohistochemistry, fluorescence in situ hybridization (FISH) and next-generation sequencing (next-generation sequencing) findings.

n = 3 cases

All 3

Results

All 3

every patient in the series relapsed, though two stabilized on TRK inhibitor therapy

n = 3 cases

More results

Mitotic activity varied from 10 to 30 per 10 high-power fields.

Immunohistochemically, all cases showed CD34 and pan-TRK positivity, and 2 cases showed patchy to diffuse S-100 staining.

“

Conclusion

The molecular identification of NTRK-rearranged neoplasms is highly significant, as patients may benefit from TRK inhibitor therapy.

Poor Prognosis and High Recurrence in NTRK3 Fusion Cervical Sarcoma: A Series of 3 Cases and Literature Review.

Poor Prognosis and High Recurrence in NTRK3 Fusion Cervical Sarcoma: A Series of 3 Cases and Literature Review.

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