The association of placental pathology and neurodevelopmental outcomes in patients with neonatal encephalopathy.

When grouped by acute, chronic, or absent placental lesions, we observed no association with in-hospital, neurodevelopmental, MRI, or EEG outcomes.

When reanalyzed by the presence of chorioamnionitis, we found that chorioamnionitis appeared to be associated with a higher risk of EEG alterations and post-neonatal epilepsy.

Despite our limited sample size, our results emphasize the critical role of placental examination for neuroprognostication in presumed hypoxic-ischemic encephalopathy.