Microvessel Density as an Adjunctive Immunohistochemical Parameter in the Differential Diagnosis of Parathyroid Carcinoma and Adenoma-An Immunohistochemical Study.
Parathyroid carcinoma was associated with higher microvessel density than parathyroid adenoma in a retrospective study
Microvessel Density as an Adjunctive Immunohistochemical Parameter in the Differential Diagnosis of Parathyroid Carcinoma and Adenoma-An Immunohistochemical Study.
Distinguishing parathyroid carcinoma from parathyroid adenoma remains a major diagnostic challenge because these tumors frequently share similar clinical, biochemical, radiological, and histopathological features.
This study evaluated the diagnostic value of tumor angiogenesis, quantified by microvessel density (microvessel density), for differentiating parathyroid carcinoma from parathyroid adenoma and its association with clinicopathological characteristics.
This retrospective study included 50 patients with primary hyperparathyroidism who underwent surgery at a tertiary endocrine surgery center, including 10 parathyroid carcinomas and 40 parathyroid adenomas.
microvessel density separates carcinoma from adenoma well; 1.0 would be perfect discrimination
Higher microvessel density was positively associated with Ki-67 expression, preoperative parathyroid hormone and calcium levels, and tumor weight, indicating a close relationship between angiogenesis, tumor proliferation, biochemical disease severity, and tumor burden.
No significant associations were observed with age or preoperative phosphate levels.
Quantitative assessment of microvessel density is a promising adjunctive immunohistochemical biomarker for distinguishing parathyroid carcinoma from parathyroid adenoma.
Incorporating microvessel density into conventional histopathological evaluation may improve diagnostic confidence, particularly in morphologically challenging cases.
Larger multicenter studies are warranted to validate these findings and further establish the clinical utility of microvessel density.