Comparative Evaluation of Immunohistochemistry With DNA Methylation Profiling for Molecular Classification of Medulloblastomas: A Single-Institution Cohort Study.

The latter comprises group 3 and group 4.

The study included 44 cases overall with a histologic diagnosis of medulloblastoma and with optimal-quality extracted tumor DNA.

The tumors were grouped into 3 molecular subgroups using immunohistochemistry for beta-catenin, YAP1, GAB1, and p53.

Four cases (12.9%) showed a WNT-activated profile, 8 (25.8%) showed an SHH-activated profile, 12 (38.7%) were group 3, and 6 (19.3%) were group 4.