Tegileridine, a Biased μ-Opioid Receptor Agonist, versus Oxycodone for Postoperative Analgesia and Postoperative Nausea and Vomiting After Total Laparoscopic Hysterectomy: A Randomized, Double-Blind, Single-Center, Controlled Trial.

Tegileridine is a recently developed biased μ-opioid receptor (MOR) agonist that may preserve analgesic efficacy while being associated with a lower incidence of opioid-related adverse effects.

To evaluate whether tegileridine, compared with oxycodone at prespecified study doses, is associated with a lower incidence of postoperative nausea and vomiting while providing similar early postoperative analgesic efficacy in patients undergoing total laparoscopic hysterectomy.