Ventilation heterogeneity under mechanical ventilation via mask during anesthetic induction: a randomized…

Randomized trialPhysiological measurement· Aug 2026

Ventilation heterogeneity under mechanical ventilation via mask during anesthetic induction: a randomized trial comparing two ventilation strategies.

Li Yang, Lingling Gao, Congxia Pan … Jun Zhang

Airway ManagementRandomized trialTreatmentQ2IF 2.8

Low tidal volume + positive end expiratory pressure mask ventilation improved lung ventilation homogeneity vs pressure-targeted strategy

Ventilation heterogeneity under mechanical ventilation via mask during anesthetic induction: a randomized trial comparing two ventilation strategies.

Li Yang … Jun Zhang

Physiological measurement · Aug 2026

Background

Low tidal volume, limited driving pressure and positive end expiratory pressure (positive end expiratory pressure) are well-accepted lung-protected ventilation strategies.

Purpose

The study aimed to compare driving pressure targeted strategy (pressure targeted strategy) and low tidal volume + positive end expiratory pressure strategy (VPS) in term of ventilation heterogeneity under mechanical ventilation via mask during anesthetic induction.

Methods

Undergoing anesthesia induction were randomly assign to either pressure targeted strategy or VPS groups.

n = 30 patients

Results

ventilation heterogeneity was lower with low tidal volume + positive end expiratory pressure than pressure-targeted ventilation

PTS

0.52GI

VPS

0.42GI

More results

An inspiration pressure of 15 cm H 2 O and zero positive end expiratory pressure was used in pressure targeted strategy group.

A tidal volume of 8 ml kg -1 predicted body weight and a positive end expiratory pressure of 5 cm H 2 O was used in VPS group.

More results

The regional lung ventilation was monitored by electrical impedance tomography (electrical impedance tomography).

Compared with spontaneous ventilation, mechanical ventilation via mask caused significant changes in the GI (0.40 ± 0.04 vs 0.48 ± 0.08, P < 0.05).

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Conclusion

Mask mechanical ventilation with VPS may improve the lung ventilation inhomogeneity during anesthetic induction when compared with pressure targeted strategy.

Ventilation heterogeneity under mechanical ventilation via mask during anesthetic induction: a randomized trial comparing two ventilation strategies.

Ventilation heterogeneity under mechanical ventilation via mask during anesthetic induction: a randomized trial comparing two ventilation strategies.

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