Effect of Gabapentin Pretreatment on Hyperalgesia in Older Patients Undergoing Sequential Bilateral Cataract…

Randomized trialJournal of clinical medicine· Jun 2026

Effect of Gabapentin Pretreatment on Hyperalgesia in Older Patients Undergoing Sequential Bilateral Cataract Surgery: A Prospective, Randomized Controlled Trial.

Seihee Min, Jiwon Han, Joo Youn Oh, Jeong-Hwa Seo

Regional AnesthesiaRandomized trialTreatmentQ2IF 3.5

Gabapentin pretreatment reduced second-eye hyperalgesia in sequential cataract surgery

Effect of Gabapentin Pretreatment on Hyperalgesia in Older Patients Undergoing Sequential Bilateral Cataract Surgery: A Prospective, Randomized Controlled Trial.

Seihee Min … Jeong-Hwa Seo

Journal of clinical medicine · Jun 2026 · Q2 in General Medicine

Background

To evaluate whether gabapentin pretreatment modulates neuronal excitability and attenuates second-eye hyperalgesia in patients undergoing sequential bilateral cataract surgery under monitored anesthesia care with retrobulbar block.

Methods

Aged > 60 years undergoing elective sequential bilateral cataract surgeries with a 1-week interval were enrolled.

n = 128 eyes

Results

gabapentin cut second-eye hyperalgesia risk by about three quarters

RR 0.24 (95% CI 0.09 to 0.63)

CI excludes the null - significant

More results

0.97 [1.96], p < 0.001).

Preoperative anxiety improved similarly in both groups before the second surgery.

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Conclusion

Gabapentin pretreatment may represent a promising strategy for reducing second-eye hyperalgesia and improving perioperative pain-related outcomes in older patients undergoing sequential bilateral cataract surgery under monitored anesthesia care with retrobulbar block.

Effect of Gabapentin Pretreatment on Hyperalgesia in Older Patients Undergoing Sequential Bilateral Cataract Surgery: A Prospective, Randomized Controlled Trial.

Effect of Gabapentin Pretreatment on Hyperalgesia in Older Patients Undergoing Sequential Bilateral Cataract Surgery: A Prospective, Randomized Controlled Trial.

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