Effects of sub-anesthetic doses of esketamine on immune function and postoperative negative emotions in acoustic neuroma patients: a randomized clinical trial.

Seventy-seven patients completed the study (39 in the esketamine group, 38 in the placebo group).

The incidences of anxiety on POD1 and 3 and sleep disturbances on POD1 were also significantly reduced ( p < 0.05).

Notably, no significant differences were observed between the two groups in terms of immune function, postoperative pain scores, or intraoperative morphine equivalent.

Adverse events did not differ between the groups.