Ciprofol versus Propofol Combined with Alfentanil for Respiratory Adverse Events in Overweight Patients…

Randomized trialDrug design, development and therapy· 2026

Ciprofol versus Propofol Combined with Alfentanil for Respiratory Adverse Events in Overweight Patients Undergoing Painless Gastroscopy: A Randomized Controlled Trial.

Yang Zhang, Dongdong Liang, Shanshan Liu … Qinxue Dai

Sedation & Anesthetic PharmacologyRandomized trialTreatmentQ1IF 6.0

Ciprofol cut respiratory adverse events versus propofol in overweight gastroscopy patients

Ciprofol versus Propofol Combined with Alfentanil for Respiratory Adverse Events in Overweight Patients Undergoing Painless Gastroscopy: A Randomized Controlled Trial.

Yang Zhang … Qinxue Dai

Drug design, development and therapy · 2026

Background

Respiratory management remains a major challenge during painless endoscopy in overweight or obese patients because of altered body fat distribution and reduced pulmonary reserve.

Purpose

This study evaluated whether ciprofol could reduce respiratory adverse events compared with propofol during painless gastroscopy in this population.

Methods

In this single-center, prospective, single-blind randomized controlled trial, 106 overweight or obese patients undergoing painless gastroscopy were randomly assigned (1:1) to receive either propofol (2 mg/kg) or ciprofol (0.4 mg/kg) following intravenous alfentanil (5 μg/kg).

n = 106 patients

Results

ciprofol nearly halved the rate of breathing complications versus propofol

Ciprofol

33.96%

Propofol

66.04%

More results

A total of 106 patients completed the study (53 per group).

No significant differences were observed in other adverse events, including nausea and vomiting.

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Conclusion · 1 of 2

In overweight or obese patients undergoing painless gastroscopy, ciprofol at 0.4 mg/kg significantly reduced respiratory adverse events, improved oxygenation, and decreased injection pain compared with propofol.

Conclusion · 2 of 2

These findings suggest that ciprofol may be a preferable anesthetic option for painless endoscopy in this population.

Ciprofol versus Propofol Combined with Alfentanil for Respiratory Adverse Events in Overweight Patients Undergoing Painless Gastroscopy: A Randomized Controlled Trial.

Ciprofol versus Propofol Combined with Alfentanil for Respiratory Adverse Events in Overweight Patients Undergoing Painless Gastroscopy: A Randomized Controlled Trial.

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