Comparison of Ciprofol and Propofol on Postoperative Quality of Recovery and Intraoperative Cerebral Oxygen…

Randomized trialDrug design, development and therapy· 2026

Comparison of Ciprofol and Propofol on Postoperative Quality of Recovery and Intraoperative Cerebral Oxygen Saturation in Patients Undergoing Thoracoscopic Thoracic Surgery: A Randomized, Double-Blind, Non-Inferiority Trial.

Lideng Guo, Lianjie Cai, Botong Ni … Ping Mo

Cardiac & Thoracic AnesthesiaRandomized trialQ1IF 6.0

Ciprofol causes far less injection pain than propofol during anesthesia induction

Comparison of Ciprofol and Propofol on Postoperative Quality of Recovery and Intraoperative Cerebral Oxygen Saturation in Patients Undergoing Thoracoscopic Thoracic Surgery: A Randomized, Double-Blind, Non-Inferiority Trial.

Lideng Guo … Ping Mo

Drug design, development and therapy · 2026

Purpose

This trial assessed whether propofol anesthesia is non-inferior to ciprofol regarding postoperative recovery quality, while additionally comparing their effects on intraoperative cerebral oxygenation.

Methods

This single-center, randomized, double-blind, non-inferiority study involved 94 patients scheduled for elective surgery, randomized equally to receive ciprofol (Group C) or propofol (Group P).

n = 94 patients

Results

injection pain was far less common with ciprofol than propofol

Ciprofol injection pai

4.5%

Propofol injection pai

59%

More results

Eighty- eight patients completed the study (Group C: 44; Group P: 44).

In ITT analysis, the mean quality of recovery-15 score at 24 hours for Group C was non-inferior to Group P ( P non-inferiority < 0.001), with consistent findings in the PP analysis.

More results

Although Group P had higher heart rates after induction of anesthesia ( P < 0.05), its average arterial pressure was notably reduced ( P < 0.05).

Notably, rScO 2 in group C was higher than that in group P after induction of anesthesia ( P = 0.046) and during the anesthesia maintenance phase ( P < 0.05).

“

Conclusion

Ciprofol is non-inferior to propofol regarding early postoperative recovery quality. Furthermore, ciprofol mitigates injection pain, reduces vasoconstrictor requirements, and better maintains cerebral oxygenation.

Comparison of Ciprofol and Propofol on Postoperative Quality of Recovery and Intraoperative Cerebral Oxygen Saturation in Patients Undergoing Thoracoscopic Thoracic Surgery: A Randomized, Double-Blind, Non-Inferiority Trial.

Comparison of Ciprofol and Propofol on Postoperative Quality of Recovery and Intraoperative Cerebral Oxygen Saturation in Patients Undergoing Thoracoscopic Thoracic Surgery: A Randomized, Double-Blind, Non-Inferiority Trial.

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