Distinct subgroups of follicular dendritic cell sarcoma: insights from clinical, histologic and immunophenotypic characterization.

Immunohistochemistry with novel markers including serglycin (serglycin), follicular dendritic cells-secreted protein (FDC-secreted protein) was applied, together with conventional follicular dendritic cells markers (CD21, CD23, CD35) and EBER.

Programmed death ligand-1 (PD-L1), a potential therapeutic marker, was additionally evaluated and scored.

Clinical and histological parameters, inflammatory cell infiltration, mitotic rate, and PD-L1 tumor proportion score (tumor proportion score) were compared statistically.

The median age was 56 years old (range, 22-80), with a female preponderance in Epstein-Barr Virus + IFDCS.