Noninvasive prediction of severe histopathology in drug-induced liver injury using a dual elastography-based machine learning model.

We developed an explainable, high-performing and dual elastography-based machine learning model to predict severe drug-induced liver injury, facilitating risk stratification and preliminary management.

KEY POINTS: Question Severe drug-induced liver injury (drug-induced liver injury) leads to a poor prognosis, yet early noninvasive identification remains challenging due to non-specific serum markers and invasive biopsy.