PRAME immunohistochemistry demonstrates high diagnostic accuracy for distinguishing melanoma from nevi but no observed association with pT stage in cutaneous melanoma: a Vietnamese clinicopathological study.

The mean age of melanoma patients was 56.4 ± 15.9 years, with a median tumor size of 30 mm.

Nodular melanoma was the most common subtype (60%), and mucosal melanoma accounted for 15.6%.

Adverse features were common, including Breslow thickness > 1 mm (87.8%), mitotic rate > 1/mm² (85.6%), and ulceration (36%).

High PRAME expression was observed in 73.3% of melanomas, whereas 97.8% of nevi were negative and none showed PRAME ≥ 2+.