Inflammatory features in placentas of women with endometriosis and their relation to maternal and neonatal…

Cohort studyPlacenta· Jun 2025

Inflammatory features in placentas of women with endometriosis and their relation to maternal and neonatal outcomes.

Liat Mor, Roni Goldenberg, Ran Keidar … Elad Barber

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Breast & Gynecologic PathologyCohort studyQ1IF 3.1

Endometriosis linked to higher rate of composite adverse neonatal outcomes.

Inflammatory features in placentas of women with endometriosis and their relation to maternal and neonatal outcomes.

Liat Mor … Elad Barber

Placenta · Jun 2025

Background

Its association with immune dysregulation and potential role in pregnancy complications remain unclear.

Purpose

This study examines the relationship between endometriosis and placental pathology to explore mechanisms underlying adverse pregnancy outcomes.

Methods

A retrospective cohort study included patients with endometriosis (n = 50) and a matched control group without endometriosis (n = 150) who delivered singleton term pregnancies at a tertiary center (2008-2023).

n = 50

Results

newborns had worse composite outcomes when mothers had endometriosis

16%

Endometriosis

4%

Control

More results

Multivariable regression confirmed associations between endometriosis, inflammatory placental features, and adverse neonatal outcomes.

“

Conclusion · 1 of 2

Endometriosis is linked to increased placental inflammatory features and higher adverse neonatal outcome rates.

Conclusion · 2 of 2

These findings highlight the need for enhanced surveillance and targeted interventions in pregnancies complicated by endometriosis.

Inflammatory features in placentas of women with endometriosis and their relation to maternal and neonatal outcomes.

Inflammatory features in placentas of women with endometriosis and their relation to maternal and neonatal outcomes.

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