Does high serum oestradiol during stimulation influence obstetrical outcomes and placental pathology in…

Cohort studyZygote (Cambridge, England)· Aug 2025

Does high serum oestradiol during stimulation influence obstetrical outcomes and placental pathology in subsequent frozen embryo transfers?

Inbal Navon, Hadas Ganer, Alexander Volodarsky-Perel … Michael H Dahan

Breast & Gynecologic PathologyCohort studyQ4IF 1.8

High oestradiol in stimulation not linked to worse obstetric outcomes after frozen transfer

Does high serum oestradiol during stimulation influence obstetrical outcomes and placental pathology in subsequent frozen embryo transfers?

Inbal Navon … Michael H Dahan

Zygote (Cambridge, England) · Aug 2025

Background

High oestradiol levels during in vitro fertilization (IVF) fresh cycles have been linked to adverse obstetric outcomes, yet whether this is due to endometrial or oocyte effects remains unclear.

Purpose

This study aimed to evaluate obstetric outcomes and placental histology in frozen embryo transfer cycles for patients with elevated serum oestradiol levels during the ovarian stimulation cycle in which the embryos were created.

Methods

A single centre retrospective cohort study of live singleton deliveries after IVF with programmed frozen embryo transfer from 2009 to 2017.

n = 114 deliveries in the high

≥10,000 pmol/L

Results

≥10,000 pmol/L

high oestradiol here did not raise the risk of adverse obstetric outcomes

n = 114 deliveries in the high

More results

Baseline demographics were comparable between groups.

No significant differences were observed in obstetric outcomes, including low birth weight, preeclampsia and preterm delivery.

The placental macroscopic and histopathological findings did not significantly differ between the groups as well.

“

Conclusion · 1 of 2

High oestradiol during the ovarian stimulation cycle used to create embryos is not associated with adverse obstetric outcomes or placental pathologies in pregnancies following frozen embryo transfer.

Conclusion · 2 of 2

This is consistent with an endometrial effect of high oestradiol and thus support the practice of a freeze all approach in high oestradiol cycles.

Does high serum oestradiol during stimulation influence obstetrical outcomes and placental pathology in subsequent frozen embryo transfers?

Does high serum oestradiol during stimulation influence obstetrical outcomes and placental pathology in subsequent frozen embryo transfers?

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