Morphologic, Immunohistochemical, and Molecular Features of Laser-Ablated Thyroid Nodules: Diagnostic Pitfalls and Differential Diagnosis with Thyroid Carcinoma.

However, thermal ablation induces marked histological alterations that may simulate thyroid malignancy, creating significant diagnostic pitfalls for pathologists.

Histopathological evaluation focused on architectural changes, nuclear atypia, capsule alterations, degenerative phenomena, and evidence of invasion.

No true capsular or vascular invasion was identified.

Thermally ablated thyroid nodules may display significant pseudo-neoplastic changes that can lead to overdiagnosis of carcinoma.