Ambulatory hypertension and left ventricular hypertrophy in pediatric chronic kidney disease: a systematic review and meta-analysis.
Ambulatory hypertension linked to nearly 3-fold higher odds of left ventricular hypertrophy in pediatric chronic kidney disease
Ambulatory hypertension and left ventricular hypertrophy in pediatric chronic kidney disease: a systematic review and meta-analysis.
UNLABELLED: Cardiovascular disease is the leading cause of mortality in pediatric patients with chronic kidney disease (chronic kidney disease).
This study aims to determine the association between ambulatory hypertension and left ventricular hypertrophy in pediatric chronic kidney disease.
hypertensive kids had nearly 3-fold higher odds of left ventricular hypertrophy than normotensive peers
The mean left ventricular mass index (left ventricular mass index) and odds of left ventricular hypertrophy was compared between normotensive and hypertensive groups.
The association between left ventricular mass index and 24-h systolic/diastolic blood pressure, day/night systolic/diastolic blood pressure, and 24-h mean arterial pressure (mean arterial pressure), was determined.
Fifty-one full text studies (n = 6509 children) were eligible for inclusion in the meta-analysis.
In children with chronic kidney disease, ambulatory hypertension is associated with elevated risk of left ventricular hypertrophy and increased left ventricular mass index.
However, there was significant heterogeneity among the included studies with respect to study design and definition of outcomes.
Timely detection of hypertensive target organ injury is imperative to mitigate future cardiovascular disease in pediatric chronic kidney disease patients. Prospero Registration: CRD 42023426891.
WHAT IS KNOWN: • Hypertension is a critical predictor of adverse cardiovascular outcomes in children with chronic kidney disease.