Nebulized nitroglycerin as an adjuvant drug in management of persistent pulmonary hypertension of newborns: a randomized controlled trial.

This is a randomized controlled trial that included 80 full-term newborns diagnosed with persistent pulmonary hypertension within 72 h after birth.

The primary outcome was the estimated systolic pulmonary artery pressure in both groups.

The nebulized nitroglycerin group exhibited a significant improvement in the oxygenation index and oxygen saturation index (OI&OSI) on days 2 and 3.

The myocardial performance index (myocardial performance index), as measured by tissue-Doppler echocardiography, was notably decreased in the nebulized nitroglycerin group on day 3.