Small quantity lipid-based nutritional supplementation and measles vaccination coverage in children aged…

Cross-sectionalNature medicine· Oct 2026

Small quantity lipid-based nutritional supplementation and measles vaccination coverage in children aged 6-23 months: a pragmatic cluster-randomized trial.

Cécile Cazes, Baba Waru Goni, Delphine Gabillard … Kevin P Q Phelan

Pediatric Infection & VaccinationCross-sectionalClinical practice

Co-delivering small-quantity lipid-based nutrient supplements with immunization increased measles vaccine coverage.

Small quantity lipid-based nutritional supplementation and measles vaccination coverage in children aged 6-23 months: a pragmatic cluster-randomized trial.

Cécile Cazes … Kevin P Q Phelan

Nature medicine · Oct 2026

Background

Undernutrition and infectious diseases pose a double threat to child survival, especially in areas with a high malnutrition burden and low vaccination coverage.

Methods

In this study, we evaluated whether distributing preventive small-quantity lipid-based nutrient supplements (SQ-LNS) alongside routine immunization services may increase vaccine uptake in a pediatric, pragmatic, cluster-randomized controlled trial in northern Nigeria.

20.1

Results

20.1

percentage-point

NutriVax led to a larger increase in MCV1 coverage compared to standard care

More results

NutriVax provided a monthly ration of SQ-LNS to children aged 6-23 months after routine National Program of Immunization delivery at primary healthcare centers.

More results

The primary outcome was coverage of the first dose of measles-containing vaccine (MCV1) verified by vaccination card among children aged 12-23 months, assessed in an endline population-based household cross-sectional survey 12 months after conducting a similar baseline survey.

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Conclusion

Co-delivering SQ-LNS with routine immunization substantially improved card-verified MCV1 uptake, supporting a scalable strategy to make progress toward targets set by the World Health Organization's Immunization Agenda 2030 in similar settings.

Small quantity lipid-based nutritional supplementation and measles vaccination coverage in children aged 6-23 months: a pragmatic cluster-randomized trial.

Small quantity lipid-based nutritional supplementation and measles vaccination coverage in children aged 6-23 months: a pragmatic cluster-randomized trial.

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