Quantitative core-level tumor burden and grading in MRI-targeted vs. systematic prostate biopsy: A within-patient paired analysis.

Within-patient studies of MRI-targeted vs. systematic prostate biopsies compare binary detection rates, but none have quantified paired tumor burden differences using continuous histopathological metrics with independent prognostic significance.

We hypothesized that MRI-targeted cores capture greater tumor burden than systematic cores within the same patient, while systematic biopsy retains an independent contribution to the detection and grading of clinically significant prostate cancer (csPCa).