Shifts in liver biopsy indications and histopathological diagnoses: A report from a tertiary care center in Türkiye.

The mean patient age was 43±15 years, with 52% being female.

The leading indications were abnormal liver function tests (53.4%), fibrosis/cirrhosis (40.9%), treatment follow-up (2.7%), hepatomegaly (1.6%), and fever of unknown origin (0.9%).

Between 2000-2011 and 2012-2022, the indications for liver biopsy changed significantly: biopsies for fibrosis/cirrhosis increased, whereas those for evaluation of treatment response and disease monitoring and for hepatomegaly decreased (p=0.01, p<0.001, and p=0.02, respectively).