Clinicopathologic features of KRAS G12C-mutated non-small cell lung carcinomas:insights from 279 retrospective cases.

Most tumors were primary lung carcinomas (n = 229, 82%), while 45 (16%) were metastatic at presentation.

Adenocarcinoma-associated patterns were present in 67 cases, often mixed, and focal solid growth occurred in 77%.

TTF1, Napsin A, and CK7 were positive in 86%, 87%, and 98%, respectively, whereas squamous markers were infrequent (p40/p63 7%, CK5/6 8%).

PD-L1 expression was detected in 65%.