Detecting Rare ALK Gene Fusions in Unclassified Spindle Cell Lung Tumors Using Anchored Multiplex… | ScholarDeck

Paper

Detecting Rare ALK Gene Fusions in Unclassified Spindle Cell Lung Tumors Using Anchored Multiplex PCR/Targeted RNA Next-Generation Sequencing.

New research · Pathology

Genes, chromosomes & cancer · 2w

StudyGenes, chromosomes & cancer· Jun 2026

Detecting Rare ALK Gene Fusions in Unclassified Spindle Cell Lung Tumors Using Anchored Multiplex PCR/Targeted RNA Next-Generation Sequencing.

Katsuhiro Masago, Katsutoshi Seto, Eiichi Sasaki … Hiroaki Kuroda

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Thoracic PathologyStudyQ1IF 2.7

ALK gene fusions found in 2 of 11 unclassified pulmonary spindle cell tumors

Detecting Rare ALK Gene Fusions in Unclassified Spindle Cell Lung Tumors Using Anchored Multiplex PCR/Targeted RNA Next-Generation Sequencing.

Katsuhiro Masago … Hiroaki Kuroda

Genes, chromosomes & cancer · Jun 2026

Background

Pulmonary spindle cell tumors are aggressive neoplasms with limited systemic treatment options, although a subset may harbor actionable genomic alterations.

Results

18.2%

ALK fusions turned up in a minority of these tumors

n = 11 surgically resected pulmonary

More results

Both tumors showed positive ALK immunohistochemical staining.

More results

Histologically, the PPFIBP1::ALK-positive tumor was composed of spindle-shaped cells with a layered architecture, whereas the SYCL3::ALK-positive tumor showed relatively round cells arranged in clusters with collagenous stroma, highlighting the morphologic heterogeneity of ALK-rearranged pulmonary spindle cell tumors.

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Conclusion

This integrated approach may refine the diagnosis and support consideration of ALK-directed therapy in these rare tumors.

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