Prognostic significance of lymphovascular space invasion extent across molecular classes in early-stage endometrial cancer: A large retrospective analysis.

Among 2374 patients, lymphovascular space invasion was absent in 73.7% (n = 1750), focal in 11.5% (n = 273), and substantial in 14.8% (n = 351).

Any lymphovascular space invasion was associated with larger tumor size, deeper myometrial invasion, and cervical involvement (all p < 0.001).

Substantial lymphovascular space invasion was additionally associated with non-endometrioid histology, grade 3 disease, ER < 10%, and higher prevalence of p53abn and NSMP-HR tumors (all p < 0.001).