Pan-TRK expression and NTRK gene aberrations in meningiomas: association with tumor grade and proliferative…

Cohort studyThe journal of pathology. Clinical research· Jul 2026

Pan-TRK expression and NTRK gene aberrations in meningiomas: association with tumor grade and proliferative activity.

Yinan Zhu, Mingfang Sun, Wanchen Lu … Xuyong Lin

Read paper

NeuropathologyCohort studyQ1IF 4.2

Pan-TRK expression more common in high-grade than low-grade meningiomas.

Pan-TRK expression and NTRK gene aberrations in meningiomas: association with tumor grade and proliferative activity.

Yinan Zhu … Xuyong Lin

The journal of pathology · Jul 2026 · Q1 in Pathology

Background

Tropomyosin receptor kinase (tropomyosin receptor kinase) fusions are actionable oncogenic drivers, and pan-tropomyosin receptor kinase immunohistochemistry (immunohistochemistry) serves as a reliable screening tool for NTRK gene aberrations.

Purpose

This study aimed to characterize pan-tropomyosin receptor kinase expression, its correlation with clinicopathological features, and underlying NTRK rearrangement status in meningiomas.

Results

nearly half of high-grade meningiomas were pan-tropomyosin receptor kinase positive, versus few grade 1 tumors

46.7%

WHO grade 2/3

14.3%

WHO grade 1

More results

We retrospectively analyzed 70 primary intracranial tumor specimens, including 50 meningiomas (21 WHO grade 1, 26 grade 2, and 3 grade 3) and 20 non-meningioma CNS tumors (9 solitary fibrous tumors, 6 hemangioblastomas, and 5 schwannomas) from the First Affiliated Hospital of China Medical University (2020-2022).

More results

Pan-TRK immunoreactivity was detected in 12/50 (24.0%) meningiomas, predominantly with cytoplasmic staining (75.0%).

No pan-tropomyosin receptor kinase expression was observed in non-meningioma tumors (0/20).

“

Conclusion

Further studies are needed to clarify the biological role of non-fusion-mediated pan-tropomyosin receptor kinase overexpression in meningioma progression.

Pan-TRK expression and NTRK gene aberrations in meningiomas: association with tumor grade and proliferative activity.

Pan-TRK expression and NTRK gene aberrations in meningiomas: association with tumor grade and proliferative activity.

Related papers