Signet ring cells can dominate follicular lymphoma, often exceeding half the tumor
Follicular lymphoma with signet ring cell morphology: Clinicopathologic analysis of 31 cases.
Xenia Parisi, L Jeffrey Medeiros
Human pathology · May 2026 · Q1 in Pathology
Methods
The cohort includes 16 women and 15 men with a median age of 65 years (range, 26-87).
n = 31 cases
Results
signet ring cells made up most of the tumor in these cases
5-10% SR cells
3cases
11-25% SR cells
8cases
26-50% SR cells
9cases
51-75% SR cells
10cases
More results
We report 31 cases of follicular lymphoma (follicular lymphoma) with signet ring (signet ring) cells, representing <0.05% of FLs diagnosed at our institution.
Twenty-three (74%) patients had advanced stage disease and 8 (26%) had localized (stage I or II) disease.
More results
Twenty-one (68%) patients underwent excisional biopsy, 8 core needle biopsy and 2 fine needle aspiration.
CD10 was positive in 28 of 30 (93%) cases, and BCL2 and BCL6 were positive in all 20 and 18 cases assessed, respectively.
“
Conclusion
We also provide results of next generation sequencing data on 4 cases which heretofore has not been reported.