EWSR1-rearranged renal neoplasia: Clinicopathologic and molecular characterization of 39 cases from a single institution.

We report the clinicopathologic features of EWSR1-rearranged renal neoplasia from our institution.

Fusion partners identified in ewing sarcoma included FLI1 (n = 17) and ERG (n = 2).

WT1 (n = 2), CREB3L1 (n = 1) and CREB3L2 (n = 1), and PATZ1 (n = 1) fusions were found in DSRCT, SEF, and TLFRCC, respectively.

The mean age at ewing sarcoma diagnosis was 31.4 years (range 6-73), with a similar sex distribution (18 females, 16 males), and a mean tumor size of 10.7 cm (range 3-24 cm).