Sanjad-Sakati Syndrome in Jordan: Clinical Features, Comorbidities, and Mortality Rate.
Nearly half of Jordanian children with Sanjad-Sakati Syndrome died, mostly from infection
Sanjad-Sakati Syndrome in Jordan: Clinical Features, Comorbidities, and Mortality Rate.
Sanjad-Sakati Syndrome (Sanjad-Sakati Syndrome) is a rare autosomal recessive disorder characterized by congenital hypoparathyroidism, dysmorphic features, and severe growth failure.
This study aims to examine the clinical picture, comorbidities, and mortality rate of Sanjad-Sakati Syndrome in Jordan.
This retrospective study included all patients diagnosed with Sanjad-Sakati Syndrome at the pediatric endocrinology clinics of Queen Rania Al Abdullah Hospital for Children, Amman, Jordan, between January 2002 and August 2025.
Of the 22 patients (age range: 4 months-23 years), 14 were male and 8 were female.
All patients presented with low birth weight, dysmorphic features, hypocalcemia, congenital hypoparathyroidism, and short stature.
Nephrocalcinosis occurred in 31.8% of the patients ( n = 7), chronic intestinal pseudo-obstruction in 22.7% ( n = 5), and subclinical hypothyroidism in 9.1% ( n = 2).
Patients with Sanjad-Sakati Syndrome in Jordan consistently presented with congenital hypoparathyroidism, developmental delay, intellectual disability, and severe growth failure.
Frequent comorbidities include nephrocalcinosis, dental anomalies, intestinal pseudo-obstruction, and complications from chronic calcium therapy. These comorbidities are associated with increased mortality rate in Sanjad-Sakati Syndrome.