Cognitive decline in community-dwelling older persons with primary age-related tauopathy: role of anatomical location of tangles and other co-existing brain pathologies.

Other brain pathologies (LATE-NC, Lewy bodies (lewy bodies), and vascular pathologies) were also evaluated.

Linear mixed effect models were employed to examine the associations between regional tau tangles and other brain pathologies with decline in global cognition and 5 cognitive domains.

Among 1,859 participants, 527 (28%) had neuropathologically confirmed primary age-related tauopathy: 385 had possible primary age-related tauopathy and 142 had definite primary age-related tauopathy, with an average age at death of 88 ± 6.9 years and 63% being female.