Neuropathological correlations of 18 F-florzolotau PET in a case with Pick’s disease.
Cortical florzolotau positron emission tomography binding correlates strongly with tau pathology at autopsy in Pick's disease
Neuropathological correlations of 18 F-florzolotau PET in a case with Pick’s disease.
Pick's disease (PiD) is classified as frontotemporal lobar degeneration with pathological tau aggregates.
In this study, we analyzed correlations between in vivo 18 F-florzolotau retentions and postmortem neuropathological data across brain regions in the same case with PiD.
Positron emission tomography (positron emission tomography) with 18 F-florzolotau provides high-contrast imaging of diverse tau fibrils.
CASE PRESENTATION: The patient was 60 years of age at the time of death and had been diagnosed with behavioral variant frontotemporal dementia.
The patient underwent 18 F-florzolotau positron emission tomography one year prior to death and was given the pathological diagnosis of PiD by brain autopsy.
Furthermore, a substantial proportion of Pick bodies displayed fluorescence co-labelled with florzolotau and AT8 antibodies.
Collectively, the present findings support the capability of 18 F-florzolotau positron emission tomography for the in vivo quantification of 3R tau fibrils.