Long-term trends in mortality of leukemia in Asia from 1992 to 2021: An age-period-cohort and population-based observational analysis of the Global Burden of Disease study 2021.

Data from the Global Burden of Disease Study (GBD) 2021 for 1992 to 2021 were used to evaluate leukemia mortality across 34 Asian countries and 5 Global Burden of Disease Study subregions.

Acute myeloid leukemia led deaths in most subregions, except East Asia, where acute lymphoblastic leukemia predominated (34.60%).

Population aging (25.46%) and growth (37.78%) drove mortality increases, while epidemiological changes reduced mortality by 44.43%.

Age-period-cohort analysis revealed a U-shaped age effect, with mortality peaking in early childhood (0-4 years: 6.22 [95% CI: 5.86-6.61] per 100 000) and older adults (90-94 years: 21.93 [95% CI: 19.85-24.22] per 100,000).