Acute Interstitial Inflammation on Skin Biopsies and Positive Tissue Cultures in Cellulitis Patients Are…

Cohort studyThe American Journal of dermatopathology· Oct 2024

Acute Interstitial Inflammation on Skin Biopsies and Positive Tissue Cultures in Cellulitis Patients Are Associated a Worse Prognosis.

Karissa Libson, Johnny Barba, Ania Henning … Catherine Chung

DermatopathologyCohort studyQ3IF 0.6

Positive tissue culture in cellulitis biopsies linked to higher 30-day mortality

Acute Interstitial Inflammation on Skin Biopsies and Positive Tissue Cultures in Cellulitis Patients Are Associated a Worse Prognosis.

Karissa Libson … Catherine Chung

The American Journal of dermatopathology · Oct 2024 · Q3 in Pathology

Background

Cellulitis is a significant public health burden and lacks a gold standard for diagnosis.

Purpose

In this study, we evaluate the histopathologic characteristics and tissue culture positivity of biopsies in patients diagnosed with cellulitis seen by our inpatient dermatology consultation service.

Methods

This retrospective cohort study examined patients who were hospitalized with a skin and soft tissue infection at our institution between 2011 and 2020 and underwent a skin biopsy.

Results

positive cultures meant far higher 30-day mortality than negative ones

Positive culture

26%

Negative culture

6%

More results

Patients who died within 30 days were more likely to have acute interstitial inflammation as a feature on histopathology (38%, P = 0.03).

“

Conclusion

Positive tissue cultures and histopathology showing acute interstitial space inflammation on skin and soft tissue infection (skin and soft tissue infection) biopsies are associated with increased mortality and thus may serve as indicators of poor prognosis.

Acute Interstitial Inflammation on Skin Biopsies and Positive Tissue Cultures in Cellulitis Patients Are Associated a Worse Prognosis.

Acute Interstitial Inflammation on Skin Biopsies and Positive Tissue Cultures in Cellulitis Patients Are Associated a Worse Prognosis.

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