Comparison of clinical and histopathological features between serum IgG4-negative and serum IgG4-positive…

Cohort studyCytoJournal· 2026

Comparison of clinical and histopathological features between serum IgG4-negative and serum IgG4-positive patients with type 1 autoimmune pancreatitis: A single-center, retrospective study.

Xiaorong Tian, Dongling Wan, Hanbin Zhu … Haojie Huang

Surgical PathologyCohort studyDiagnosisQ2IF 1.7

Serum IgG4-negative type 1 pancreatitis patients had higher CA19-9 levels than IgG4-positive patients

Comparison of clinical and histopathological features between serum IgG4-negative and serum IgG4-positive patients with type 1 autoimmune pancreatitis: A single-center, retrospective study.

Xiaorong Tian … Haojie Huang

CytoJournal · 2026 · Q2 in Pathology

Purpose

In type 1 autoimmune pancreatitis (autoimmune pancreatitis), serum immunoglobulin G4 (IgG4) has a complex correlation with pathology.

Methods

A retrospective analysis was performed on 78 type 1 autoimmune pancreatitis patients (screened from 160 eligible cases through inclusion/exclusion criteria, International Consensus Diagnostic Criteria-confirmed at Changhai Hospital (December 2019-2023).

n = 19

32.14

Results

32.14

vs. 5.97 U/mL

Median CA19-9, a tumor marker, was higher in seronegative than seropositive patients (P=0.035)

n = 19

More results

No significant differences in sex, age, most comorbidities (e.g., hypertension), or symptoms (e.g., abdominal discomfort) were observed between the serum IgG4-N and serum IgG4-P groups (all P > 0.050).

More results

The 84.75% vs 52.63% ( P = 0.010) represents the EUS examination receiving rate between serum IgG4-P and serum IgG4-N groups, rather than the diagnostic positive rate of FNA/FNB subtypes.

8 cells per high-power field (high-power field), P = 0.035).

“

Conclusion · 1 of 3

Serum IgG4 typing is associated with the clinical-pathological features of type 1 autoimmune pancreatitis. The serum IgG4-P group often shows biliary duct stenosis and diffuse pancreatic enlargement, with a reliance on EUS puncture.

Conclusion · 2 of 3

The serum IgG4-N group has higher CA19-9 and a higher surgical rate. Pathological examination remains critical (no serum-tissue IgG4 association).

Conclusion · 3 of 3

This study supports optimized, accurate diagnosis and stratified management of type 1 autoimmune pancreatitis.

Comparison of clinical and histopathological features between serum IgG4-negative and serum IgG4-positive patients with type 1 autoimmune pancreatitis: A single-center, retrospective study.

Comparison of clinical and histopathological features between serum IgG4-negative and serum IgG4-positive patients with type 1 autoimmune pancreatitis: A single-center, retrospective study.

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