Clinicopathological features and impact on surgical axillary management of encapsulated papillary carcinoma of the breast.
Axillary lymph node metastases affected 13.2% of patients, all with invasive disease.
Clinicopathological features and impact on surgical axillary management of encapsulated papillary carcinoma of the breast.
Encapsulated papillary carcinoma (encapsulated papillary carcinoma) is a rare breast malignancy accounting for approximately 0.5-1% of all breast cancers.
To evaluate the clinicopathological and imaging characteristics of encapsulated papillary carcinoma, assess the frequency of associated invasive disease and axillary lymph node involvement, and determine their impact on surgical axillary management and oncological outcomes.
Were classified as pure encapsulated papillary carcinoma, encapsulated papillary carcinoma associated with ductal carcinoma in situ (ductal carcinoma in situ), or invasive encapsulated papillary carcinoma.
invasive disease raised the risk of cancer spread to underarm nodes
Histopathological evaluation demonstrated pure encapsulated papillary carcinoma in 22 patients (19%), encapsulated papillary carcinoma associated with ductal carcinoma in situ in 17 (15%), and invasive encapsulated papillary carcinoma in 74 (65%).
Most patients were postmenopausal, and the majority of tumors exhibited favorable biological characteristics, including high hormone receptor positivity and low HER2 expression.
Encapsulated papillary carcinoma is an uncommon breast malignancy with an overall favorable prognosis, but it remains a diagnostically and therapeutically challenging entity because of its heterogeneous pathological spectrum and the variable presence of associated invasive carcinoma.
It needs individualized axillary management, with routine axillary staging potentially unnecessary in carefully selected patients with pure encapsulated papillary carcinoma, while invasive encapsulated papillary carcinoma warrants more comprehensive surgical assessment.