CO₂ laser ablation versus conization for cervical intraepithelial neoplasia grade 2: a prospective cohort study.

The primary outcome was short-term histopathological treatment response (regression to CIN1 or normal histology) at a 6-month follow-up.

The overall treatment response rate was 81.5%, with no statistically significant difference between the conization (89.1%) and laser ablation (78.0%) groups (p = 0.108).

In the laser group specifically, abnormal cytology, older age, and a BMI ≥ 25 kg/m² were significant predictors of treatment failure.

CO₂ laser ablation demonstrated acceptable short-term efficacy for managing CIN2, with no statistically significant difference compared with conization at six months of follow-up.