Transrectal Ultrasound-Guided Prostate Biopsy: Sextant versus 12-Core Protocol.
Extended 12-core prostate biopsy detected 21.8% more cancers than sextant biopsy alone.
Transrectal Ultrasound-Guided Prostate Biopsy: Sextant versus 12-Core Protocol.
In Nigeria, prostate cancer is the most diagnosed cancer in males from middle age.
This study aimed to compare cancer detection rates between sextant and extended 12-core biopsy protocols using transrectal ultrasound-guided needle biopsy amongst patients being evaluated for prostate cancer in Lagos University Teaching Hospital, Lagos.
This study was a prospective comparative hospital-based study involving patients evaluated for prostate cancer.
extended biopsy found more cancers than sextant biopsy alone
In total, 78 men (58.2%) tested positive for cancer, 52 men had benign prostatic hyperplasia (benign prostatic hyperplasia), and four men had prostatitis.
Of the 78 patients positive for prostate cancer, six-sextant biopsy protocol detected 61 (78.2%), and six-lateral-directed biopsies detected 77 (98.7%), showing an improvement of 17 (20.5%) of six-lateral biopsies over six-sextant biopsy protocol.
This was statistically significant ( P < 0.001).
This study showed that men with prostate cancer were older, had smaller prostates, and had higher prostate-specific antigen range levels.
Increasing the number of cores taken on prostate biopsy is associated with an increase in cancer detection rate, as the extended 12-core biopsy protocol outperformed the conventional sextant protocol significantly.
The improvement in detection rate was most marked in lower prostate-specific antigen ranges ≤20 ng/mL. Screening modalities for prostate cancer had better predictive value for prostate cancer detection in their combination.