Preliminary results and experiences of fluorescence confocal microscopy using the Histolog® Scanner in prostate cancer diagnostics: a feasibility study.

The Histolog Scanner shows promise as a rapid tool for the preliminary assessment of prostate biopsy cores, showing high negative predictive value and sensitivity; however, the positive predictive value and specificity turned out to be relatively low.

Tissue integrity is preserved for subsequent histopathology. The limitations of our study highlight the need for larger prospective studies to refine its clinical role and determine optimal integration into PCa diagnostic workflows.