Antibiotic stewardship and safety in office-based transrectal prostate biopsy: a single-center retrospective…

Cohort studyJournal of medicine and life· Apr 2026

Antibiotic stewardship and safety in office-based transrectal prostate biopsy: a single-center retrospective analysis of complications.

Osama Salloum, Romica Cergan, Nicoleta Aurelia Sanda … Adrian Costache

Genitourinary PathologyCohort studyDiagnosis

Fusion biopsy detected prostate cancer in numerically more men than systematic biopsy, but not significantly

Antibiotic stewardship and safety in office-based transrectal prostate biopsy: a single-center retrospective analysis of complications.

Osama Salloum … Adrian Costache

Journal of medicine and life · Apr 2026

Background

Multiparametric magnetic resonance imaging has improved risk stratification and lesion-directed sampling in suspected prostate cancer.

Purpose

This study aimed to compare the diagnostic yield of fusion and systematic biopsy in a single-center paired cohort and to explore biopsy-to-surgical pathology concordance in operated patients.

Methods

This retrospective study included 138 men who underwent both fusion-targeted and systematic biopsy during the same diagnostic work-up.

n = 138 men

Results

fusion found cancer in more men, but the gap wasn't statistically significant

Fusion biopsy

47.1%

Systematic biopsy

40.6%

More results

Fusion-only detection occurred in 16 patients (11.6%) and systematic-only detection in 7 (5.1%).

The paired difference for overall cancer detection did not reach statistical significance (exact McNemar P = 0.093).

More results

Clinically significant prostate cancer was detected in 37/138 men (26.8%) by fusion biopsy and 35/138 (25.4%) by systematic biopsy ( P = 0.815).

Surgical pathology was available in 45 patients; upgrading occurred in 21 (46.7%) and adverse pathology in 18 (40.0%).

“

Conclusion

Current evidence also suggests that careful antibiotic stewardship is a safe approach in the management of office-based transrectal prostate biopsy.

Antibiotic stewardship and safety in office-based transrectal prostate biopsy: a single-center retrospective analysis of complications.

Antibiotic stewardship and safety in office-based transrectal prostate biopsy: a single-center retrospective analysis of complications.

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