Diagnostic Accuracy of Prognostic Nutritional Index and Systemic Immune-Inflammatory Index in Predicting Fibrosis and Histological Activity in Chronic Hepatitis B.
Systemic immune-inflammatory index moderately predicts severe liver inflammation in chronic hepatitis B
Diagnostic Accuracy of Prognostic Nutritional Index and Systemic Immune-Inflammatory Index in Predicting Fibrosis and Histological Activity in Chronic Hepatitis B.
Liver biopsy remains the gold standard for staging chronic hepatitis B (chronic hepatitis B), yet it is invasive, costly, and associated with potential complications.
This study aimed to evaluate the correlation between the Prognostic Nutritional Index (Prognostic Nutritional Index) and Systemic Immune-Inflammatory Index (SII) with histological fibrosis stages and the Histological Activity Index (Histological Activity Index) in patients with chronic hepatitis B.
This retrospective study analyzed 274 patients diagnosed with chronic hepatitis B (HBsAg positivity > 6 months) who underwent liver biopsy at the University of Health Sciences, Kanuni Sultan Süleyman Training and Research Hospital between February 2016 and February 2022.
higher scores flag severe inflammation well, though not reliably enough to use alone
The cohort comprised 119 females (43.4%) and 155 males (56.6%), with a mean age of 45.25 ± 11.2 years.
Mean values were 55.83 ± 5.33 for Prognostic Nutritional Index and 494.37 ± 336.86 for SII.
For fibrosis staging, SII demonstrated statistically significant but limited predictive ability for Ishak scores ≥F2, while Prognostic Nutritional Index was significant for identifying advanced fibrosis (≥F4) ( p < 0.05).
Both indices were associated with histological parameters but showed limited overall diagnostic performance. SII appeared relatively better; however, this was descriptively observed without formal statistical comparison.
These markers may provide complementary information but should not be used as standalone diagnostic tools.