Cytokeratin-18 increase as a signal for early liver cell changes in high-fat diet-induced obesity before overt steatohepatitis.

The major cause of non-alcoholic fatty liver disease (non-alcoholic fatty liver disease) is obesity; in fact, this condition has been defined as metabolic dysfunction-associated steatotic liver disease (MASLD).

This study aimed to evaluate the metabolic parameters, CK-18 levels, and liver histopathology in high-fat diet-induced obesity in rats.