A Novel Anti-Cadherin-19 Monoclonal Antibody (Ca 19 Mab-8) for Flow Cytometry, Western Blotting, and… | ScholarDeck

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A Novel Anti-Cadherin-19 Monoclonal Antibody (Ca 19 Mab-8) for Flow Cytometry, Western Blotting, and Immunohistochemistry.

New research · Pathology

Current issues in molecular biology · 3w

Animal / preclinicalCurrent issues in molecular biology· Mar 2026

A Novel Anti-Cadherin-19 Monoclonal Antibody (Ca 19 Mab-8) for Flow Cytometry, Western Blotting, and Immunohistochemistry.

Guanjie Li, Hiroyuki Suzuki, Mika K Kaneko, Yukinari Kato

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HematopathologyAnimal / preclinicalQ2IF 4.3

New antibody Ca 19 Mab-8 binds cell-surface CDH19 with high affinity

A Novel Anti-Cadherin-19 Monoclonal Antibody (Ca 19 Mab-8) for Flow Cytometry, Western Blotting, and Immunohistochemistry.

Guanjie Li … Yukinari Kato

Current issues in molecular biology · Mar 2026 · Q2 in General Medicine

Background

The type II cadherin Cadherin-19 (CDH19) plays a crucial role in neural crest development.

9.0 × 10-9 M

Results

9.0 × 10-9 M

antibody binds CDH19 tightly, indicating high affinity

More results

CDH19 regulates cell-cell junctions and migration by forming catenin-cytoskeleton complexes.

Here, novel anti-human CDH19 mAbs (Ca 19 Mabs) were created using flow cytometry-based high-throughput screening.

Additionally, Ca 19 Mab-8 recognized endogenous CDH19 in the human glioblastoma cell line LN229.

More results

Ca 19 Mab-8 also detected endogenous CDH19 in Western blotting.

“

Conclusion

Therefore, Ca 19 Mab-8 has potential for clinical diagnosis and tumor therapy.

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