Case Report: A case of non-secretory multiple myeloma presenting with eosinophilia: diagnostic challenges… | ScholarDeck

Paper

Case Report: A case of non-secretory multiple myeloma presenting with eosinophilia: diagnostic challenges and a focused literature review.

New research · Pathology

Frontiers in oncology · 3w

Case reportFrontiers in oncology· 2026

Case Report: A case of non-secretory multiple myeloma presenting with eosinophilia: diagnostic challenges and a focused literature review.

Jirui Zhong, Xikun Liu, Jiduo Liu … Zenghui Liu

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HematopathologyCase reportDiagnosisQ2IF 3.1

Non-secretory myeloma with eosinophilia showed only 6.1% clonal plasma cells in marrow.

Case Report: A case of non-secretory multiple myeloma presenting with eosinophilia: diagnostic challenges and a focused literature review.

Jirui Zhong … Zenghui Liu

Frontiers in oncology · 2026

Results

6.1%

very few marrow plasma cells were clonal, easy to miss on standard testing

More results

We report a rare case of non-secretory multiple myeloma (non-secretory multiple myeloma) presenting with marked eosinophilia and considerable diagnostic difficulty.

A 56-year-old man was admitted with recurrent low back pain of more than 10 years' duration that had rapidly worsened over the preceding 10 days, accompanied by diffuse pain and weight loss.

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However, serum and urine immunofixation electrophoresis were negative, qualitative urine Bence-Jones protein testing was negative, and repeated serum free light chain testing showed a normal κ/λ ratio, making the diagnosis particularly challenging.

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Conclusion

We also reviewed the limited literature on MM-associated eosinophilia to underscore the importance of integrating bone marrow findings, imaging, and cytogenetic evaluation in atypical cases.

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