DNA Methylation Signatures of Upper Aerodigestive Tract Squamous Cell Carcinoma and Sarcomatoid Squamous Cell Carcinoma Are Similar: A Potential Novel Diagnostic Tool for the Diagnosis of Sarcomatoid Squamous Cell Carcinoma.

21 upper aerodigestive tract squamous cell carcinoma samples from 15 patients were retrieved (9 M, 6 F; 47-88 years, median 71 years) from sites including tongue (7), larynx (5), pharynx (3), maxillary/mandibular alveolar ridge (3), "neck" (2), and nasal cavity (1).

Of the sarcomatous components, six were entirely negative (score = 0) for all keratins performed.

Methylomes of sarcomatoid carcinoma of upper aerodigestive tract and cutaneous origin overlapped.

Copy number profile analysis did not show significant differences between conventional and sarcomatoid histologies or tumor time point.