Hetairos is a histology-based artificial intelligence model for predicting central nervous system tumor methylation subtypes.

However, this requires more resources and time than conventional hematoxylin and eosin (H&E) histopathology, which is widely available globally.

Here we propose Hetairos, an artificial intelligence algorithm that predicts 102 methylation-based central nervous system tumor subtypes from digital H&E slides.

Built and validated on 9,606 patients and over 11,000 slides from 11 centers across four continents, Hetairos identified 50-70% of cases with high confidence, achieving an accuracy of 0.87 for its highest-rated predictions.