Hyperphosphorylated tau and amyloid-β proteinopathy in people over age 50: Findings from the Lieber…

Cohort studyJournal of Alzheimer's disease : JAD· Feb 2026

Hyperphosphorylated tau and amyloid-β proteinopathy in people over age 50: Findings from the Lieber Institute for Brain Development Brain Donation Repository.

Rudolph J Castellani, Rahul A Bharadwaj, Amanda O Fisher-Hubbard … Grant L Iverson

NeuropathologyCohort studyQ1IF 3.2

About 1 in 4 people in their 80s had advanced tau pathology at autopsy.

Hyperphosphorylated tau and amyloid-β proteinopathy in people over age 50: Findings from the Lieber Institute for Brain Development Brain Donation Repository.

Rudolph J Castellani … Grant L Iverson

Journal of Alzheimer's disease · Feb 2026 · Q1 in General Medicine

Background

The Lieber Institute for Brain Development (Lieber Institute for Brain Development) has one of the largest postmortem human brain banks for the study of neuropsychiatric disorders in the world.

Purpose

Present the Lieber Institute for Brain Development semiquantitative assessment methodology for p-tau and Aβ by comparing proteinopathy by age and by apolipoprotein E ( APOE ) genotype.

Methods

Postmortem brain tissue samples were from 1509 people aged 50 or greater (median age at death = 63 years; range = 50-102).

n = 1509 people

Results

roughly 1 in 4 in their 80s had advanced tau pathology at death

63.8%

B1 (modified Braak I o

30.4%

B2 (modified Braak III

5.8%

B3 (modified Braak V o

More results

For those in their early 70 s, half had modified Braak stage III-IV ratings.

Age and APOE genotype were significant predictors of Aβ plaques.

“

Conclusion · 1 of 2

The Lieber Institute for Brain Development protocol assessing p-tau and Aβ burden identified significant associations with age and APOE genotype.

Conclusion · 2 of 2

More research is needed to understand the spectrum of age-related proteinopathy versus neurodegenerative disease neuropathology.

Hyperphosphorylated tau and amyloid-β proteinopathy in people over age 50: Findings from the Lieber Institute for Brain Development Brain Donation Repository.

Hyperphosphorylated tau and amyloid-β proteinopathy in people over age 50: Findings from the Lieber Institute for Brain Development Brain Donation Repository.

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