Diagnostic yield and safety of frame-based versus robot-assisted stereotactic brain biopsy: a matched cohort analysis.
Robot-assisted brain biopsy linked to more transient symptomatic complications than frame-based.
Diagnostic yield and safety of frame-based versus robot-assisted stereotactic brain biopsy: a matched cohort analysis.
Frame-based stereotactic biopsy has long been the gold standard for diagnostic brain biopsy, whereas robot-assisted stereotactic techniques have emerged as promising alternatives.
To compare the diagnostic yield and complication rates of frame-and robot-assisted stereotactic brain biopsy using a rigorously matched cohort methodology.
This retrospective, bicentric, comparative analysis included adult patients who underwent stereotactic brain biopsy between January 2011 and December 2019.
Higher odds of temporary symptomatic complications with robot-assisted versus frame-based biopsy.
Each patient who underwent robot-assisted biopsy (n = 230) was matched in a 2:1 ratio with patients who underwent frame-based biopsy (n = 460).
The diagnostic yield was identical for both techniques 97.4%, with a non-diagnostic biopsy rate of 2.6% in each group (p = 1.0).
No differences were found in symptomatic hemorrhage, infection, seizures, permanent neurological deficits, or mortality between groups.
Although robot-assisted biopsies were associated with a higher incidence of transient symptomatic complications, both techniques exhibited favorable safety profiles with respect to severe complications.
The choice of technique should consider the surgeon's experience, institutional resources, and integration within existing workflows.