Histopathological Evidence of Neurodegenerative Pathology in Epilepsy: A Systematic Review. | ScholarDeck

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Histopathological Evidence of Neurodegenerative Pathology in Epilepsy: A Systematic Review.

New research · Pathology

Annals of clinical and translational neurology · 3w

ReviewAnnals of clinical and translational neurology· Jul 2026

Histopathological Evidence of Neurodegenerative Pathology in Epilepsy: A Systematic Review.

Syeda Amrah Hashmi, Aleksander Luniewski, Vanessa Smith … Ifrah Zawar

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P-tau pathology prevalence varies widely across epilepsy cases, ranging from 3% to 95%.

Histopathological Evidence of Neurodegenerative Pathology in Epilepsy: A Systematic Review.

Syeda Amrah Hashmi … Ifrah Zawar

Annals of clinical and translational neurology · Jul 2026

Background

Epilepsy affects > 50 million people worldwide and is associated with a disproportionate burden of cognitive impairment.

Methods

We conducted a systematic review of neuropathological studies examining neurodegenerative pathology in PWE without primary neurodegenerative disease.

Results

3%-95%

how often p-tau shows up in epilepsy brains swings enormously between studies

More results

However, the prevalence, distribution, and clinical significance of these proteins in epilepsy remain unclear.

Two reviewers independently screened studies, extracted data, and assessed risk of bias.

Forty-two studies met the inclusion criteria.

More results

Most studies involved drug-resistant temporal lobe epilepsy (temporal lobe epilepsy) with hippocampal sclerosis.

“

Conclusion

The review followed PRISMA guidelines and was registered

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