Nestin expression in nodular and acral lentiginous melanoma: associations with ulceration and invasion…

StudyActa dermatovenerologica Alpina, Pannonica, et Adriatica· Mar 2026

Nestin expression in nodular and acral lentiginous melanoma: associations with ulceration and invasion factors in Mexican patients.

Araceli Barrera-Jacome, Fernando Fernandez-Ramirez, Miguel A Pardiño-Vega, Norma E Herrera-Gonzalez

DermatopathologyStudyQ3IF 0.9

Nodular melanoma strongly associated with 37.5-fold higher risk of ulceration

Nestin expression in nodular and acral lentiginous melanoma: associations with ulceration and invasion factors in Mexican patients.

Araceli Barrera-Jacome … Norma E Herrera-Gonzalez

Acta dermatovenerologica Alpina, Pannonica, et Adriatica · Mar 2026 · Q3 in General Medicine

Background

There are still many gaps in the understanding of melanoma subtypes in Mexico.

Methods

Immunohistochemistry using a polyclonal antibody was performed on selected paraffin blocks.

37.5-fold

Results

37.5-fold

nodular subtype means far higher odds the tumor is ulcerated

More results

Eighty-three melanoma cases were diagnosed based on clinical and histopathological criteria: 47 were nodular melanoma, and 36 were acral lentiginous melanoma.

High nestin expression was mainly found in nodular melanoma (p = 0.0001).

More results

A lower but relevant level of nestin expression was observed in acral lentiginous melanoma, which has rarely been reported in the literature.

“

Conclusion

Elevated nestin expression was statistically associated with nodular melanoma and a deeper Clark level of invasion. In addition, it was significantly linked to an increased risk of histological ulceration.

Nestin expression in nodular and acral lentiginous melanoma: associations with ulceration and invasion factors in Mexican patients.

Nestin expression in nodular and acral lentiginous melanoma: associations with ulceration and invasion factors in Mexican patients.

Related papers