Perioperative Factor VIII Replacement in Severe Hemophilia A During Neonatal Supracardiac Total Anomalous…

Case reportJournal of cardiothoracic and vascular anesthesia· Jun 2026

Perioperative Factor VIII Replacement in Severe Hemophilia A During Neonatal Supracardiac Total Anomalous Pulmonary Venous Connection Repair.

Is'haq Al Aamri, Madan Mohan Maddali, Hajer Nasser Al Nasseri … Hamood Nasar Al-Kindi

Perioperative MedicineCase reportQ2IF 1.6

Factor VIII levels reached 200% to 300% perioperatively without bleeding or clotting complications.

Perioperative Factor VIII Replacement in Severe Hemophilia A During Neonatal Supracardiac Total Anomalous Pulmonary Venous Connection Repair.

Is'haq Al Aamri … Hamood Nasar Al-Kindi

Journal of cardiothoracic and vascular anesthesia · Jun 2026 · Q2 in Anesthesiology

Background

Neonatal cardiac surgery in severe hemophilia A remains rarely reported, with limited data guiding perioperative coagulation management during cardiopulmonary bypass.

Purpose

This report describes neonatal repair of supracardiac total anomalous pulmonary venous connection in genetically confirmed severe hemophilia A using a structured, assay-guided intermittent-bolus recombinant factor VIII strategy rather than continuous infusion.

Results

200%

to 300%

factor VIII stayed far higher than normal, yet no bleeding or clots followed

“

Conclusion

This approach challenges the prevailing preference for continuous infusion and offers a pragmatic, resource-adaptable strategy for managing congenital coagulopathy in high-risk neonatal cardiac surgery.

Perioperative Factor VIII Replacement in Severe Hemophilia A During Neonatal Supracardiac Total Anomalous Pulmonary Venous Connection Repair.

Perioperative Factor VIII Replacement in Severe Hemophilia A During Neonatal Supracardiac Total Anomalous Pulmonary Venous Connection Repair.

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