The ED 90 of Oliceridine for Tracheal Intubation in Children: A Biased-Coin Up-and-Down Parallel…

Randomized trialDrug design, development and therapy· 2026

The ED 90 of Oliceridine for Tracheal Intubation in Children: A Biased-Coin Up-and-Down Parallel Dose-Finding Study.

Liqun Cheng, Jing Jiang, Mengqi Li … Kan Zhang

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Airway ManagementRandomized trialTreatmentQ1IF 6.0

The 90% effective dose of oliceridine for pediatric tracheal intubation is 74.3 μg/kg.

The ED 90 of Oliceridine for Tracheal Intubation in Children: A Biased-Coin Up-and-Down Parallel Dose-Finding Study.

Liqun Cheng … Kan Zhang

Drug design, development and therapy · 2026

Background

Oliceridine as a novel biased μ-opioid receptors agonist that selectively activates G protein-mediated signaling, has been associated with a lower incidence of opioid-related adverse events (opioid-related adverse events).

Methods

In this prospective, double-blind, sequential allocation study, 100 children scheduled for general anesthesia were enrolled.

n = 100 children

Results

Dose of oliceridine needed to achieve stable hemodynamics in 90% of children during intubation.

ED90 74.30 (95% CI 73.60 to 77.40)

CI excludes the null - significant

More results

The incidences of hemodynamic changes were comparable between groups before and after tracheal intubation.

No hypoxemia was observed after administration of oliceridine and sufentanil.

All adverse events were self-limited and no intervention was required.

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Conclusion

Oliceridine at an ED 90 of 74.3 μg/kg can be effectively used for tracheal intubation during pediatric anesthesia.

The ED 90 of Oliceridine for Tracheal Intubation in Children: A Biased-Coin Up-and-Down Parallel Dose-Finding Study.

The ED 90 of Oliceridine for Tracheal Intubation in Children: A Biased-Coin Up-and-Down Parallel Dose-Finding Study.

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